Murray, who was fifth at the Cape Town leg three weeks ago, will face a formidable line-up which includes series leader Javier Gomez of Spain and defending Yokohama champion Jonathan Brownlee of Great Britain.
Brownlee’s brother, Olympic gold medallist Alistair, returns from an Achilles injury and Portugal’s Joao Silva, who won in Yokohama in 2011 and 2012, are also expected to offer a strong challenge.
Murray will be joined in the 67-man field by fellow South Africans Henri Schoeman, Wian Sullwald and Wikus Weber.
Gillian Sanders will lead the SA charge in the women’s race, after finishing 15th in Cape Town, along with Carlyn Fischer.
Former world champion Jodie Stimpson of Great Britain, unbeaten in the series this season, and American Gwen Jorgensen, who won in Yokohama last year, will line up as the favourites in the 54-strong women’s field.
Today’s event will offer competitors the first chance to earn rankings points for the 2016 Rio Olympics.