After finishing third last year, Dr KK continued their fine run of form at the Bellville Velodrome with a 56-45 victory over their fancied Gauteng opponents.
They were two points clear at the top of the standings, with four matches to play in the round robin phase of the tournament.
Defending champions Mangaung Metro and Gauteng North, losing finalists last year, were in a tie for second place.
Boland were a further two points behind with a game in hand, while at the opposite end of the table, Gauteng West were the only top-flight team without a point.
Results of A-section matches at the National Netball Championships in Cape Town yesterday:
Dr Kenneth Kaunda 72 – Gauteng West 28
Buffalo City 38 – Nelson Mandela Bay 36
Mangaung Metro 47 – Western Province 38
Umgungundlovu 59 – Frances Baard 51
Gauteng North 62 – Boland 39
Mangaung Metro 51 – Nelson Mandela Bay 38
Dr Kenneth Kaunda – 56 Gauteng North 45
Umgungundlovu 50 – Gauteng West 43
Boland 57 – Frances Baard 43
Western Province 34 – Buffalo City 28