Anderson will play in the last 16 at the Australian Open for the third year in a row, while Nadal, a 14-time Grand Slam champion, is in search of his second title at Melbourne Park.
Here are some interesting statistics about both players ahead of their clash:
Anderson is bidding to become the first South African man to reach the singles quarter-finals at a Grand Slam since Wayne Ferreira achieved the feat at Melbourne Park in 2003.
- The SA men’s No 1 is looking to become the fifth South African in history, after Cliff Drysdale, Johan Kriek, Kevin Curren and Wayne Ferreira, to reach the Australian Open semifinals.
- Anderson is aiming to defeat a top 10 player at a Grand Slam for the first time in 14 attempts. The highest-ranked player he has defeated at a major is No 15 Fabio Fognini at Wimbledon last year.
- Nadal has not lost to a player seeded as low as No 14 at a Grand Slam tournament since losing to No 23 seed Robin Soderling in the last 16 at the French Open in 2009.
- Nadal has never lost a set against a South African opponent in three previous meetings with SA players.