Kickoff: 7.30pm (SA TIME)
Inconsistent team selection cost the Boks dearly with prop Beast Mtawarira and hooker and captain Adriaan Strauss the only players to have featured in all 12 Tests.
Strauss will play his 66th and final Test in a career that has spanned eight years since 2008 and he would be desperate to fire the team on to just their fifth win in their 12th Test.
The Boks have played the Welsh 31 times with the Boks winning 28, Wales just two and one game ending in a draw.
Wales’ only two wins came in 1999 when they won 29-19 and again 15 years later in 2014 when they won 12-6.
Bok coach Allister Coetzee has handed debuts to centre Rohan Janse van Rensburg, wing Jamba Ulengo and flank Uzair Cassiem, while loose forward Jean-Luc du Preez could also earn his first cap should he come off the bench.
Should the Boks lose today it will be their eighth loss of the season, the most SA has suffered in their history in one season, with this season’s seven defeats already on par with the seven losses of 2006 under former coach Jake White.
The bookmakers have predicted a Wales win of between 5-10 points.
Referee: Romain Poite (France)
Wales: 15 Leigh Halfpenny, 14 George North, 13. Jonathan Davies, 12 Scott Williams, 11 Liam Williams, 10 Dan Biggar, 9 Gareth Davies, 8 Ross Moriarty, 7 Justin Tipuric, 6 Dan Lydiate, 5 Alun Wyn Jones, 4 Luke Charteris, 3 Tomas Francis, 2 Ken Owens, 1 Gethin Jenkins (captain)
Substitutes: 16 Scott Baldwin, 17 Nicky Smith, 18 Samson Lee, 19 Cory Hill, 20 Taulupe Faletau, 21 Lloyd Williams, 22 Sam Davies, 23 Jamie Roberts
South Africa: 15 Johan Goosen, 14 Ruan Combrinck, 13 Francois Venter, 12 Rohan Janse van Rensburg, 11 Jamba Ulengo, 10 Elton Jantjies, 9 Faf de Klerk, 8 Warren Whiteley, 7 Uzair Cassiem, 6 Nizaam Carr, 5 Lood de Jager, 4 Pieter-Steph du Toit, 3 Lourens Adriaanse, 2 Adriaan Strauss (captain), 1 Tendai Mtawarira
Substitutes: 16 Malcolm Marx, 17 Steven Kitshoff, 18 Trevor Nyakane, 19 Franco Mostert, 20 Jean-Luc du Preez, 21 Piet van Zyl, 22 Pat Lambie, 23 Lionel Mapoe