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June 26: On This Day in World History … briefly

The Human Genome Project was a 13-year-long, publicly funded project initiated in 1990 with the objective of determining the DNA sequence of the entire euchromatic human genome within 15 years.

2000:  The Human Genome Project announces completion of a ‘rough draft’ sequence

The Human Genome Project (HGP) was an international scientific research project with the goal of determining the sequence of nucleotide base pairs that make up human DNA, and of identifying and mapping all of the genes of the human genome from both a physical and a functional standpoint. It remains the world’s largest collaborative biological project.

DNA replication – Wikipedia

After the idea was picked up in 1984 by the US government when the planning started, the project formally launched in 1990 and was declared complete on April 14, 2003. Funding came from the US government through the National Institutes of Health (NIH) as well as numerous other groups from around the world. A parallel project was conducted outside government by the Celera Corporation, or Celera Genomics, which was formally launched in 1998. Most of the government-sponsored sequencing was performed in twenty universities and research centers in the United States, the United Kingdom, Japan, France, Germany and China.

The structure of the DNA double helix. Atoms in the structure are colour-coded by element and the detailed structures of two base pairs are shown in the bottom right – Wikipedia

The Human Genome Project originally aimed to map the nucleotides contained in a human haploid reference genome (more than three billion). The ‘genome’ of any given individual is unique; mapping the ‘human genome’ involved sequencing a small number of individuals and then assembling these together to get a complete sequence for each chromosome. Therefore, the finished human genome is a mosaic, not representing any one individual.

Logo of the Human Genome Project or HGP – the Vitruvian Man by Leonardo da Vinci – Wikipedia
Most notable historic snippets or facts extracted from the book ‘On This Day’ first published in 1992 by Octopus Publishing Group Ltd, London, as well as additional supplementary information extracted from Wikipedia.

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