The Scottish player has breezed through matches against David Goffin, Blaz Rola and Roberto Bautista Agut, but things could get tricky when he faces big-serving Anderson.
The South African, seeded 20, has belted 63 aces in three rounds and while his serve is his big weapon he is also more than capable off the ground. World No. 5 Murray knows his first big test is around the corner.
“I haven’t used up too much energy which is good,” said the Scot who will feature in the second match on Centre Court on Monday.
“It will be a tough match,” Murray told reporters. “He’s a big guy with a big game. He’s played some very good tennis this year.
“It’s probably been his best year on the tour so far in terms of consistency. I’ll need to play a tough match to beat him.”
