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Sisi, who was elected president in 2014 a year after heading the military ouster of Islamist leader Mohamed Morsi, on Friday confirmed he would be seeking a second four-year term.
Sisi is the only candidate so far to officially submit an application to the National Election Authority for the March 26-28 election, the third since strongman Hosni Mubarak was toppled by a 2011 uprising.
Hopefuls must register by January 29, but a number of possible Sisi opponents have already either ruled themselves out or been targeted for prosecution.
On Tuesday a bid by General Sami Anan was plunged into doubt after the armed forces accused him on state television of “infractions and crimes” that require investigation.
The authorities issued a gag order on the details of his case which is being handled by military judiciary.
High-profile names to drop out include former Mubarak-era prime minister Ahmed Shafiq and Mohamed Anwar Sadat, a dissident and nephew of the former president of the same name.
Shafiq reversed a pledge to run after he was returned to Egypt from exile in the United Arab Emirates, while Sadat said the climate was not right for free elections.
Last month a military court sentenced Colonel Ahmed Konsowa to six years in jail after he announced his intention to stand.
There still remain two well-known people still potentially in the running: rights lawyer and 2012 presidential candidate Khaled Ali and Mortada Mansour, the head of Egypt’s legendary Zamalek football club.
Ali’s campaign is scheduled to announce at a press conference later on Wednesday whether he will withdraw or continue with his bid.
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