It is believed that the protesters are from Qolweni and that the action is over housing issues.
A riot in Plettenberg Bay that began on Monday night has now flared up again, Knysna Plett Herald reports.
It is believed the protesters are from Qolweni, and that the protest action is related to housing issues.
READ MORE: Plettenberg Bay homes destroyed in fire
Police are on the scene and busy dispersing the crowd.
The N2 is closed from Ladywood to the traffic circle at the Shell Ultra City.
Traffic is being redirected via Wittedrift/Avontuur road and via Airport road until further notice.
Motorists have also been warned to take care when travelling in the vicinity of Qolweni/Bossiesgif and industrial area, and to report suspicious activity.
For more news your way, follow The Citizen on Facebook and Twitter.