The trio picked up injuries in the midweek league win against Platinum Stars and are doubtful for this encounter.
Sundowns coach Pitso Mosimane has admitted it will be a major blow to lose these players, but added it should never be an excuse in Saturday’s crucial match.
“It would be a blow if we were to miss all three players at the same time, especially that our schedule is this tight, but we can never use that as an excuse,” Mosimane told the club’s website.
“As long as we have eleven players on the field and seven substitutes, we have to fight on.”
The game is set to take place at Loftus Versfeld Stadium on Saturday at 6pm.