Itumeleng Khune and Reyaad Pieterse (Photo by Lefty Shivambu/Gallo Images)
Itumeleng Khune withdrew from the squad after coming down with a chest infection, while Darren Keet suffered a knee injury.
South Africa will play against Cape Verde on September 1, 2017, at the Estadio Nacional Stadium in Cape Verde.
The return leg will be played four days later on September 5 at the Moses Mabhida Stadium in Durban.
“Bafana Bafana goalkeepers Itumeleng Khune and Darren Keet have been withdrawn from the squad that will take on Cape Verde in back to back 2018 Fifa World Cup qualifiers,” Safa confirmed on their official website.