Manyama was injured in January just when he looked to be finding his rhythm at the team.
“Players like Lebo Manyama and (Mulomowandau) Mathoho… they are excellent. It is a blow to not have them. But that is the situation (we have to live with),” said Middendorp when asked last Friday.
“I hope Manyama will make some appearance maybe in sometime in April,” he added.
Amakhosi are likely to be chasing on two fronts by then – with both the Absa Premiership and Nedbank Cup still a possibility for the Naturena based side.
Chiefs play Cape Town City in the quarter finals at Mbombela Stadium on March 31.